The role of maternal antibodies in the emergence of severe disease as a result of fragmentation
Identifieur interne : 000318 ( France/Analysis ); précédent : 000317; suivant : 000319The role of maternal antibodies in the emergence of severe disease as a result of fragmentation
Auteurs : David Fouchet [France] ; Stphane Marchandeau [France] ; Nargs Bahi-Jaber [France] ; Dominique Pontier [France]Source :
- Journal of The Royal Society Interface [ 1742-5689 ] ; 2006.
Abstract
Population fragmentation is a major problem for the conservation of mammalian species. Since the spread of an infectious disease is related to the intensity of contacts between individuals, fragmentation destabilizes the way the parasites circulate in their host population. Recently, Zinkernagel has proposed that a reduction in the frequency of infections by a parasite could lead to the emergence of severe forms of the disease, previously avoided because the disease was contracted early in life and attenuated by maternal antibodies. However, it is still unclear whether this change in disease expression increases the global mortality it induces because the disease becomes more severe and also less frequent. Here, we use a mathematical model to link population fragmentation with the hypothesis of Zinkernagel. Firstly, we show that there is a change in the severity of the disease during the fragmentation process, especially at a local scale, suggesting that host population fragmentation could be a widespread mechanism of disease emergence. Secondly, we show that the emergence of the severe form of the disease can lead to a significant increase in its induced mortality. Finally, we determine the types of interactions for which the fragmentation of the host population could be the most dangerous.
Url:
DOI: 10.1098/rsif.2006.0189
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001330
- to stream Istex, to step Curation: 001330
- to stream Istex, to step Checkpoint: 001570
- to stream Main, to step Merge: 004360
- to stream Main, to step Curation: 004144
- to stream Main, to step Exploration: 004144
- to stream France, to step Extraction: 000318
Links to Exploration step
ISTEX:36CA09C3AF4915CDB18C881C6C8E59FA87A1E904Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of maternal antibodies in the emergence of severe disease as a result of fragmentation</title>
<author><name sortKey="Fouchet, David" sort="Fouchet, David" uniqKey="Fouchet D" first="David" last="Fouchet">David Fouchet</name>
</author>
<author><name sortKey="Marchandeau, Stphane" sort="Marchandeau, Stphane" uniqKey="Marchandeau S" first="Stphane" last="Marchandeau">Stphane Marchandeau</name>
</author>
<author><name sortKey="Bahi Jaber, Nargs" sort="Bahi Jaber, Nargs" uniqKey="Bahi Jaber N" first="Nargs" last="Bahi-Jaber">Nargs Bahi-Jaber</name>
</author>
<author><name sortKey="Pontier, Dominique" sort="Pontier, Dominique" uniqKey="Pontier D" first="Dominique" last="Pontier">Dominique Pontier</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:36CA09C3AF4915CDB18C881C6C8E59FA87A1E904</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1098/rsif.2006.0189</idno>
<idno type="url">https://api.istex.fr/ark:/67375/V84-CMCVQ83R-Z/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001330</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001330</idno>
<idno type="wicri:Area/Istex/Curation">001330</idno>
<idno type="wicri:Area/Istex/Checkpoint">001570</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001570</idno>
<idno type="wicri:doubleKey">1742-5689:2006:Fouchet D:the:role:of</idno>
<idno type="wicri:Area/Main/Merge">004360</idno>
<idno type="wicri:Area/Main/Curation">004144</idno>
<idno type="wicri:Area/Main/Exploration">004144</idno>
<idno type="wicri:Area/France/Extraction">000318</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">The role of maternal antibodies in the emergence of severe disease as a result of fragmentation</title>
<author><name sortKey="Fouchet, David" sort="Fouchet, David" uniqKey="Fouchet D" first="David" last="Fouchet">David Fouchet</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>UMR-CNRS 5558, Universit Lyon 143 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Villeurbanne</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">France</country>
</affiliation>
</author>
<author><name sortKey="Marchandeau, Stphane" sort="Marchandeau, Stphane" uniqKey="Marchandeau S" first="Stphane" last="Marchandeau">Stphane Marchandeau</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Office National de la Chasse et de la Faune Sauvage44000 Nantes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bahi Jaber, Nargs" sort="Bahi Jaber, Nargs" uniqKey="Bahi Jaber N" first="Nargs" last="Bahi-Jaber">Nargs Bahi-Jaber</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>UMR-CNRS 5558, Universit Lyon 143 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Villeurbanne</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pontier, Dominique" sort="Pontier, Dominique" uniqKey="Pontier D" first="Dominique" last="Pontier">Dominique Pontier</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>UMR-CNRS 5558, Universit Lyon 143 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Villeurbanne</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of The Royal Society Interface</title>
<idno type="ISSN">1742-5689</idno>
<idno type="eISSN">1742-5662</idno>
<imprint><publisher>The Royal Society</publisher>
<pubPlace>London</pubPlace>
<date type="e-published">2006</date>
<date type="published">2007</date>
<biblScope unit="vol">4</biblScope>
<biblScope unit="issue">14</biblScope>
<biblScope unit="page" from="479">479</biblScope>
<biblScope unit="page" to="489">489</biblScope>
</imprint>
<idno type="ISSN">1742-5689</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1742-5689</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Population fragmentation is a major problem for the conservation of mammalian species. Since the spread of an infectious disease is related to the intensity of contacts between individuals, fragmentation destabilizes the way the parasites circulate in their host population. Recently, Zinkernagel has proposed that a reduction in the frequency of infections by a parasite could lead to the emergence of severe forms of the disease, previously avoided because the disease was contracted early in life and attenuated by maternal antibodies. However, it is still unclear whether this change in disease expression increases the global mortality it induces because the disease becomes more severe and also less frequent. Here, we use a mathematical model to link population fragmentation with the hypothesis of Zinkernagel. Firstly, we show that there is a change in the severity of the disease during the fragmentation process, especially at a local scale, suggesting that host population fragmentation could be a widespread mechanism of disease emergence. Secondly, we show that the emergence of the severe form of the disease can lead to a significant increase in its induced mortality. Finally, we determine the types of interactions for which the fragmentation of the host population could be the most dangerous.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Villeurbanne</li>
</settlement>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Fouchet, David" sort="Fouchet, David" uniqKey="Fouchet D" first="David" last="Fouchet">David Fouchet</name>
</region>
<name sortKey="Bahi Jaber, Nargs" sort="Bahi Jaber, Nargs" uniqKey="Bahi Jaber N" first="Nargs" last="Bahi-Jaber">Nargs Bahi-Jaber</name>
<name sortKey="Fouchet, David" sort="Fouchet, David" uniqKey="Fouchet D" first="David" last="Fouchet">David Fouchet</name>
<name sortKey="Marchandeau, Stphane" sort="Marchandeau, Stphane" uniqKey="Marchandeau S" first="Stphane" last="Marchandeau">Stphane Marchandeau</name>
<name sortKey="Pontier, Dominique" sort="Pontier, Dominique" uniqKey="Pontier D" first="Dominique" last="Pontier">Dominique Pontier</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000318 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000318 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= France |étape= Analysis |type= RBID |clé= ISTEX:36CA09C3AF4915CDB18C881C6C8E59FA87A1E904 |texte= The role of maternal antibodies in the emergence of severe disease as a result of fragmentation }}
This area was generated with Dilib version V0.6.33. |